ICD-10 Diagnosis Code D68.61

Antiphospholipid syndrome

Diagnosis Code D68.61

ICD-10: D68.61
Short Description: Antiphospholipid syndrome
Long Description: Antiphospholipid syndrome
This is the 2018 version of the ICD-10-CM diagnosis code D68.61

Valid for Submission
The code D68.61 is valid for submission for HIPAA-covered transactions.

Code Classification
  • Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50–D89)
    • Coagulation defects, purpura and other hemorrhagic conditions (D65-D69)
      • Other coagulation defects (D68)

Information for Medical Professionals

Diagnostic Related Groups
The diagnosis code D68.61 is grouped in the following Diagnostic Related Group(s) (MS-DRG V35.0)


Convert to ICD-9 Additional informationCallout TooltipGeneral Equivalence Map
The ICD-10 and ICD-9 GEMs are used to facilitate linking between the diagnosis codes in ICD-9-CM and the new ICD-10-CM code set. The GEMs are the raw material from which providers, health information vendors and payers can derive specific applied mappings to meet their needs.

  • Antiphospholipid syndrome
  • Antiphospholipid syndrome in pregnancy
  • Catastrophic antiphospholipid syndrome
  • Primary antiphospholipid syndrome
  • Primary antiphospholipid syndrome with multisystem involvement
  • Primary antiphospholipid syndrome with organ/system involvement
  • Secondary antiphospholipid syndrome
  • Secondary antiphospholipid syndrome with multisystem involvement
  • Secondary antiphospholipid syndrome with organ/system involvement
  • Thrombophilia due to antiphospholipid antibody

Index of Diseases and Injuries
References found for the code D68.61 in the Index of Diseases and Injuries:

Information for Patients

Bleeding Disorders

Also called: Clotting disorders

Normally, if you get hurt, your body forms a blood clot to stop the bleeding. For blood to clot, your body needs cells called platelets and proteins known as clotting factors. If you have a bleeding disorder, you either do not have enough platelets or clotting factors or they don't work the way they should.

Bleeding disorders can be the result of other diseases, such as severe liver disease or a lack of vitamin K. They can also be inherited. Hemophilia is an inherited bleeding disorder. Bleeding disorders can also be a side effect of medicines such as blood thinners.

Various blood tests can check for a bleeding disorder. You will also have a physical exam and history. Treatments depend on the cause. They may include medicines and transfusions of blood, platelets, or clotting factor.

  • Bleeding disorders (Medical Encyclopedia)
  • Bleeding time (Medical Encyclopedia)
  • Disseminated intravascular coagulation (DIC) (Medical Encyclopedia)
  • Partial thromboplastin time (PTT) (Medical Encyclopedia)
  • Prothrombin time (PT) (Medical Encyclopedia)


Blood Clots

Also called: Hypercoagulability

Normally, if you get hurt, your body forms a blood clot to stop the bleeding. After the bleeding stops and healing takes place, your body usually breaks down and removes the clot. But some people get too many clots or their blood clots abnormally. Many conditions can cause the blood to clot too much or prevent blood clots from dissolving properly.

Risk factors for excessive blood clotting include

  • Certain genetic disorders
  • Atherosclerosis
  • Diabetes
  • Atrial fibrillation
  • Overweight, obesity, and metabolic syndrome
  • Some medicines
  • Smoking
  • Staying in one position for a long time, such as being in the hospital or taking a long car or plane ride
  • Cancer and cancer treatments
Blood clots can form in, or travel to, the blood vessels in the brain, heart, kidneys, lungs, and limbs. A clot in the veins deep in the limbs is called deep vein thrombosis (DVT). DVT usually affects the deep veins of the legs. If a blood clot in a deep vein breaks off and travels through the bloodstream to the lungs and blocks blood flow, it is called a pulmonary embolism. Other complications of blood clots include stroke, heart attack, kidney problems, kidney failure, and pregnancy-related problems.Treatments for blood clots include blood thinners and other medicines.

  • Arterial embolism (Medical Encyclopedia)
  • Blood clots (Medical Encyclopedia)
  • D-dimer test (Medical Encyclopedia)
  • Prothrombin time (PT) (Medical Encyclopedia)
  • Superficial thrombophlebitis (Medical Encyclopedia)
  • Thrombophlebitis (Medical Encyclopedia)


Antiphospholipid syndrome Antiphospholipid syndrome is a disorder characterized by an increased tendency to form abnormal blood clots (thromboses) that can block blood vessels. This clotting tendency is known as thrombophilia. In antiphospholipid syndrome, the thromboses can develop in nearly any blood vessel in the body, but most frequently occur in the vessels of the lower limbs. If a blood clot forms in the vessels in the brain, blood flow is impaired and can lead to stroke. Antiphospholipid syndrome is an autoimmune disorder. Autoimmune disorders occur when the immune system attacks the body's own tissues and organs.Women with antiphospholipid syndrome are at increased risk of complications during pregnancy. These complications include pregnancy-induced high blood pressure (preeclampsia), an underdeveloped placenta (placental insufficiency), early delivery, or pregnancy loss (miscarriage). In addition, women with antiphospholipid syndrome are at greater risk of having a thrombosis during pregnancy than at other times during their lives. At birth, infants of mothers with antiphospholipid syndrome may be small and underweight.A thrombosis or pregnancy complication is typically the first sign of antiphospholipid syndrome. This condition usually appears in early to mid-adulthood but can begin at any age.Other signs and symptoms of antiphospholipid syndrome that affect blood cells and vessels include a reduced amount of cell fragments involved in blood clotting called platelets (thrombocytopenia), a shortage of red blood cells (anemia) due to their premature breakdown (hemolysis), and a purplish skin discoloration (livedo reticularis) caused by abnormalities in the tiny blood vessels of the skin. In addition, affected individuals may have open sores (ulcers) on the skin, migraine headaches, heart disease, or intellectual disability. Many people with antiphospholipid syndrome also have other autoimmune disorders such as systemic lupus erythematosus.Rarely, people with antiphospholipid syndrome develop thromboses in multiple blood vessels throughout their body. These thromboses block blood flow in affected organs, which impairs their function and ultimately causes organ failure. These individuals are said to have catastrophic antiphospholipid syndrome (CAPS). CAPS typically affects the kidneys, lungs, brain, heart, and liver, and is fatal in over half of affected individuals. Less than 1 percent of individuals with antiphospholipid syndrome develop CAPS.
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