ICD-10 Diagnosis Code R53.0

Neoplastic (malignant) related fatigue

Diagnosis Code R53.0

ICD-10: R53.0
Short Description: Neoplastic (malignant) related fatigue
Long Description: Neoplastic (malignant) related fatigue
This is the 2018 version of the ICD-10-CM diagnosis code R53.0

Valid for Submission
The code R53.0 is valid for submission for HIPAA-covered transactions.

Code Classification
  • Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00–R99)
    • General symptoms and signs (R50-R69)
      • Malaise and fatigue (R53)

Information for Medical Professionals

According to ICD-10-CM guidelines this code should not to be used as a principal diagnosis code when a related definitive diagnosis has been established.
Diagnostic Related Groups
The diagnosis code R53.0 is grouped in the following Diagnostic Related Group(s) (MS-DRG V35.0)


Convert to ICD-9 Additional informationCallout TooltipGeneral Equivalence Map
The ICD-10 and ICD-9 GEMs are used to facilitate linking between the diagnosis codes in ICD-9-CM and the new ICD-10-CM code set. The GEMs are the raw material from which providers, health information vendors and payers can derive specific applied mappings to meet their needs.

  • Fatigue due to chemotherapy or radiation therapy
  • Fatigue due to treatment

Index of Diseases and Injuries
References found for the code R53.0 in the Index of Diseases and Injuries:

Information for Patients


Also called: Carcinoma, Malignancy, Neoplasms, Tumor

Cancer begins in your cells, which are the building blocks of your body. Normally, your body forms new cells as you need them, replacing old cells that die. Sometimes this process goes wrong. New cells grow even when you don't need them, and old cells don't die when they should. These extra cells can form a mass called a tumor. Tumors can be benign or malignant. Benign tumors aren't cancer while malignant ones are. Cells from malignant tumors can invade nearby tissues. They can also break away and spread to other parts of the body.

Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. Most cancers are named for where they start. For example, lung cancer starts in the lung, and breast cancer starts in the breast. The spread of cancer from one part of the body to another is called metastasis. Symptoms and treatment depend on the cancer type and how advanced it is. Most treatment plans may include surgery, radiation and/or chemotherapy. Some may involve hormone therapy, immunotherapy or other types of biologic therapy, or stem cell transplantation.

NIH: National Cancer Institute

  • Cancer (Medical Encyclopedia)
  • Cancer and lymph nodes (Medical Encyclopedia)
  • Cancer treatment -- early menopause (Medical Encyclopedia)
  • Cancer treatment: preventing infection (Medical Encyclopedia)
  • Cancer treatments (Medical Encyclopedia)
  • How to research cancer (Medical Encyclopedia)
  • How to tell your child that you have cancer (Medical Encyclopedia)
  • Hyperthermia for treating cancer (Medical Encyclopedia)
  • Laser therapy for cancer (Medical Encyclopedia)
  • Photodynamic therapy for cancer (Medical Encyclopedia)
  • Targeted therapies for cancer (Medical Encyclopedia)
  • Understanding your cancer prognosis (Medical Encyclopedia)
  • Your cancer care team (Medical Encyclopedia)
  • Your cancer diagnosis: Do you need a second opinion? (Medical Encyclopedia)



Also called: Tiredness, Weariness

Everyone feels tired now and then. Sometimes you may just want to stay in bed. But, after a good night's sleep, most people feel refreshed and ready to face a new day. If you continue to feel tired for weeks, it's time to see your doctor. He or she may be able to help you find out what's causing your fatigue and recommend ways to relieve it.

Fatigue itself is not a disease. Medical problems, treatments, and personal habits can add to fatigue. These include

  • Taking certain medicines, such as antidepressants, antihistamines, and medicines for nausea and pain
  • Having medical treatments, like chemotherapy and radiation
  • Recovering from major surgery
  • Anxiety, stress, or depression
  • Staying up too late
  • Drinking too much alcohol or too many caffeinated drinks
  • Pregnancy

One disorder that causes extreme fatigue is chronic fatigue syndrome (CFS). This fatigue is not the kind of tired feeling that goes away after you rest. Instead, it lasts a long time and limits your ability to do ordinary daily activities.

NIH: National Institute on Aging

  • Coping with cancer -- managing fatigue (Medical Encyclopedia)
  • Fatigue (Medical Encyclopedia)

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